Khwai River Lodge is situated in the Moremi Game Reserve which is well regarded as one of Africa's finest and most beautiful reserves.  It covers an area of untouched wilderness including approximately twenty percent of the Okavango Delta itself.

The reserve has a wide diversity of ecosystems but the game here is the principle attraction; Moremi is widely acknowledged as the predator capital of the world. Literally teeming with other game the reserve is also the only place in Botswana where the big five can be seen.

Elephant and both species of rhinocerous are present along with good herds of buffalo, wildebeest and zebra. Plenty of antelope such as waterbuck, kudu and red lechwe provide ample opportunity for the vast numbers of predators with large prides of lion, leopard and cheetah regularly spotted on game drives along with resident packs of wildog and hyaena within Moremi.